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KMID : 1147720090020020159
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Journal of Acupuncture and Meridian Studies
2009 Volume.2 No. 2 p.159 ~ p.164
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Toxicity Studies on Secretio Bufonis: A Traditional Supplement in Asia
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Yoo Won-Seung
Kim Jung-Sun
Lee Yeon-Weol
Yoon Dae-Hwan
Cho Chong-Kwan
Yoo Hwa-Seung
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Abstract
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Objectives: This study was performed to investigate the toxicity of Secretio Bufonis (SB) on male mice and assess its no-observed-adverse-effect-level (NOAEL).
Materials and Methods: After feeding an aqueous solution of SB extracts to mice for either 1 or 8 weeks, their blood and urine were assayed and their liver and kidney morphology examined. The numerical data was analyzed by the Mann-Whitney U-test and analysis of variance test.
Results: Mice administered SB in 50 mg/kg/day for 1 week had higher heart weights and higher aspartate transaminase activities; those administered SB in 0.01 and 0.05 mg/kg/day for 8 weeks had lower creatinine concentrations; and those administered SB in 0.5 mg/kg/day for 8 weeks had higher brain weights and higher blood urea nitrogen.
Conclusions: The extracts of SB had cardiac toxicity in the short term and hepatotoxicity in the long term. The NOAEL of the extract was under 5 mg/kg/day for 1 week and under 0.25 mg/kg/day for 8 weeks.
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KEYWORD
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amphibian venoms, in vivo, no-observed-adverse-effect-level, Secretio Bufonis, toxicity
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